Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | Western blot, Luciferase reporter assay etc. |
| Sample | cell line (HUVEC) |
| Expression Pattern | differential expression |
| Function Description | PVT1 affected cell proliferation, migration and in vitro vascular tube formation of HUVECs.In addition,it was determined that PVT1 was able to bind and degrade miR-26b to promote connective tissue growth factor (CTGF) and angiopoietin 2 (ANGPT2) expression.miR-26b was also identified to have a suppressive role in cell proliferation,migration and in vitro vascular tube formation of HUVECs via binding 3'-UTR regions and downregulating CTGF and ANGPT2 expression levels.PVT1 was important in angiogenesis of vascular endothelial cell as ceRNA to bind and degrade miR-26b,which expanded the current understanding of PVT1 as ceRNA to regulate biological processes. |
| Pubmed ID | 29620147 |
| Year | 2018 |
| Title | lncRNA PVT1 promotes the angiogenesis of vascular endothelial cell by targeting miR-26b to activate CTGF/ANGPT2. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |