Basic Information
LncRNA/CircRNA Name | PVT1 |
Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
Region | GRCh38_8:127794533-128101253 |
Ensemble | ENSG00000249859 |
Refseq | NR_003367 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | gemcitabine | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | pancreatic cancer |
ICD-0-3 | C25 |
Methods | qPCR, Western blot etc. |
Sample | cell line (BxPC3, MiaPaCa2, Panc1, PDAC, BxPC3) |
Expression Pattern | up-regulated |
Function Description | Here, we report the re-sensitization of chemoresistant PDAC cells by curcumin through the inhibition of the PRC2-PVT1-c-Myc axis. Using gemcitabine-resistant PDAC cell lines, we found that curcumin sensitized chemoresistant cancer cells by inhibiting the expression of the PRC2 subunit EZH2 and its related lncRNA PVT1. Curcumin was also found to prevent the formation of spheroids, a hallmark of CSCs, and to down-regulate several self-renewal driving genes. In addition, we confrmed our in vitro fndings in a xenograft mouse model where curcumin inhibited gemcitabine-resistant tumor growth. Overall, this study indicates clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC. |
Pubmed ID | 29048549 |
Year | 2017 |
Title | Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression |
External Links
Links for PVT1 | GenBank HGNC NONCODE |
Links for pancreatic cancer | OMIM COSMIC |