Basic Information
| LncRNA/CircRNA Name | BDNF-AS |
| Synonyms | BDNF-AS, ANTI-BDNF, BDNF, BDNF-AS1, BDNFAS, BDNFOS, NCRNA00049 |
| Region | GRCh38_11:27506838-27698174 |
| Ensemble | ENSG00000245573 |
| Refseq | NR_002832 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, Cell proliferation assay, Cell cycle assay etc. |
| Sample | RB tissues, cell lines (ARPE-19, hTERT-RPE1, Y79, WERI-Rb-1, Rb116, Rb143, SO-RB50 and HXO-RB44) |
| Expression Pattern | down-regulated |
| Function Description | BDNF-AS is downregulated in RB tumors and cell lines. Low BDNF-AS expression in RB tumors is correlated with patients' advanced clinical stage and tumor differentiation status. Low BDNF-AS expression is associated with shorter overall survival and may be acting as an independent marker in RB. In Y79 and WERI-Rb-1 cells, forced overexpression of BDNF-AS inhibited cancer proliferation and migration. It also induced cell-cycle arrest at G0/G1 phase by downregulating CDC42, Cyclin E and BDNF. |
| Pubmed ID | 28131827 |
| Year | 2017 |
| Title | Long noncoding RNA BDNF-AS is a potential biomarker and regulates cancer development in human retinoblastoma. |
External Links
| Links for BDNF-AS | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |