Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay, RIP |
| Sample | cell lines (H1650, A549, H1975, and H358, BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 knockdown remarkably inhibited cell viability, invasion and promoted apoptosis in NSCLC cells.PVT1 could directly interact with miR-497.Moreover, PVT1 overexpression reversed the inhibitory effect of miR-497 on cell viability, invasion and promotion effect on apoptosis of NSCLC cells. knockdown of PVT1 inhibited tumor growth in vivo and promoted miR-497 expression.In human gastric cancer, PVT1 expression was found to serve as an independent predictor for overall survival. |
| Pubmed ID | 29133127 |
| Year | 2017 |
| Title | Knockdown of LncRNA PVT1 inhibits tumorigenesis in non-small-cell lung cancer by regulating miR-497 expression. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |