Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot |
| Sample | pancreatic cancer tissues, cell line (PANC-1) |
| Expression Pattern | up-regulated |
| Function Description | It showed that plasmacytoma variant translocation 1 (PVT1) expression was significantly upregulated in pancreatic cancer tissues or cell line compared to normal groups. PVT1 promoted epithelial-mesenchymal transition and cell proliferation and migration through downregulating p21 in pancreatic cancer cells. |
| Pubmed ID | 28355965 |
| Year | 2017 |
| Title | Long Noncoding RNA PVT1 Promotes EMT and Cell Proliferation and Migration Through Downregulating p21 in Pancreatic Cancer Cells |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |