Basic Information
| LncRNA/CircRNA Name | PVT1-214 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR , Western blot , in vitro knockdown etc. |
| Sample | gastric cancer tissues ,cell lines(SGC-7901, MKN-45 cells, BGC-823),normal human gastric mucosal epithelial cells (GES-1) |
| Expression Pattern | up-regulated |
| Function Description | PVT1-214 expression in GC tissues and cell lines is markedly elevated. In GC patients, high expression of PVT1-214 is associated with late tumor stage, increased tumor size, and poor survival.PVT1-214 silencing represses cell proliferation and enhances apoptosis of GC cells both in vivo and in vitro. Additionally, PVT1-214 functions as a competing endogenous RNA (ceRNA) by binding to miR-128. |
| Pubmed ID | 31173288 |
| Year | 2019 |
| Title | Long Noncoding RNA PVT1-214 Enhances Gastric Cancer Progression by Upregulating TrkC Expression in Competitively Sponging Way |
External Links
| Links for PVT1-214 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |