Basic Information
| LncRNA/CircRNA Name | PXN-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:120201291-120213138 |
| Ensemble | ENSG00000255857 |
| Refseq | NR_038924 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | GBM tissues compared to the paired normal tissues, cell lines (A172, U251, U87, LN229,NHA) |
| Expression Pattern | up-regulated |
| Function Description | PXN-AS1 was highly expressed in GBM tissues and cells. Besides, the knock-down of PXN-AS1 was closely associated with the inhibitory proliferation and inducing apoptosis of GBM cells. PXN-AS1 inhibition was also found to restrain GBM tumour growth. |
| Pubmed ID | 32329150 |
| Year | 2020 |
| Title | SOX9-activated PXN-AS1 promotes the tumorigenesis of glioblastoma by EZH2-mediated methylation of DKK1. |
External Links
| Links for PXN-AS1 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |