Basic Information
| LncRNA/CircRNA Name | PYCARD-AS1 |
| Synonyms | NA |
| Region | GRCh38_16:31201885-31203452 |
| Ensemble | ENSG00000261359 |
| Refseq | NR_102400 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RIP , in vitro knockdown etc. |
| Sample | cell lines(HEK293T, SKBR3, T47D, MDA-MB-231 and MCF7) |
| Expression Pattern | NA |
| Function Description | PYCARD-AS1 is an lncRNA distributed in both nucleus and cytoplasm.PYCARD-AS1 is a negative regulator of PYCARD.PYCARD-AS1 regulates PYCARD at the epigenetic level.PYCARD-AS1 regulates apoptosis in a PYCARD-dependent manner, indicating that PYCARD is a critical downstream target of PYCARD-AS1.Mechanistically, PYCARD-AS1 can localize to the PYCARD promoter, where it facilitates DNA methylation and H3K9me2 modification by recruiting the chromatin-suppressor proteins DNMT1 and G9a. |
| Pubmed ID | 31086376 |
| Year | 2019 |
| Title | A long noncoding RNA distributed in both nucleus and cytoplasm operates in the PYCARD-regulated apoptosis by coordinating the epigenetic and translational regulation |
External Links
| Links for PYCARD-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |