Basic Information
| LncRNA/CircRNA Name | RBM5-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:50099603-50100988 |
| Ensemble | ENSG00000281691 |
| Refseq | NR_045388 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | RT-qPCR, Luciferase activity assays, Western blot assay |
| Sample | OSCC tumor tissues,OSCC cancer cell lines, Tca8113, SCC9, SCC25, CAL27, HN12, HSU3, FADU, and normal human oral keratinocytes NHOK cell |
| Expression Pattern | up-regulated |
| Function Description | lncRNA RBM5-AS1 to be highly expressed in OSCC tumor tissues and cancer cell lines. RBM5-AS1 promotes the proliferation, migration, and invasion of OSCC cells in vitro. We also found that RBM5-AS1 regulates the level of miR-1285-3p as a competitive endogenous RNA (ceRNA), therefore regulate the expression level of an oncogene-YAP1, a target of miR-1285-3p. |
| Pubmed ID | 31869662 |
| Year | 2020 |
| Title | Long Non-Coding RNA RBM5-AS1 Promotes the Aggressive Behaviors of Oral Squamous Cell Carcinoma by Regulation of miR-1285-3p/YAP1 Axis |
External Links
| Links for RBM5-AS1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |