Basic Information
| LncRNA/CircRNA Name | RBM5-AS1 |
| Synonyms | RBM5-AS1, LUST |
| Region | GRCh38_3:50099603-50100988 |
| Ensemble | ENSG00000281691 |
| Refseq | NR_045388 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Cell transfection, Dual luciferase reporter assay, Flow cytometry assay etc. |
| Sample | cell lines (LS174T, SW480, HT-29, CaCo-2, DLD-1 and HCT 116) |
| Expression Pattern | differential expression |
| Function Description | In this study, we report enrichment of the lncRNA RBM5-AS1/LUST during sphere formation of colon CIC. Its silencing impaired WNT signaling, whereas its overexpression enforced WNT signaling, cell growth, and survival in serum-free media. Mechanistic investigations showed that silencing or overexpression of RBM5-AS1 caused a respective loss or retention of B-catenin from TCF4 complexes bound to the WNT target genes SGK1, YAP1, and MYC Our work suggests that RBM5-AS1 activity is critical for the functional enablement of colon cancer stem-like cells. Furthermore, it defines the mechanism of action of RBM5-AS1 in the WNT pathway via physical interactions with B-catenin, helping organize transcriptional complexes that sustain colon CIC function. |
| Pubmed ID | 27520449 |
| Year | 2016 |
| Title | RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells. |
External Links
| Links for RBM5-AS1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |