Basic Information
| LncRNA/CircRNA Name | RGMB-AS1 |
| Synonyms | RGMB antisense RNA 1 |
| Region | GRCh38_5:98769618-98773469 |
| Ensemble | ENSG00000246763 |
| Refseq | NR_033932 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Luciferase Reporter Assay, RIP |
| Sample | glioma tissues,glioma cell lines and normal human astrocyte cell line (NHA) |
| Expression Pattern | up-regulated |
| Function Description | RGMB-AS1 was upregulated in glioma tissues and associated with glioma grade and patients' prognosis. Moreover, RGMB-AS1 silencing significantly inhibited the proliferation, migration and invasion of glioma cells. RGMB-AS1 downregulation led to more tumor cells arrested in the quiescent state. Mechanistically, we found that RGMB-AS1 was a molecular sponge for miR-1200. MiR-1200 level was inhibited by RGMB-AS1. |
| Pubmed ID | 31819505 |
| Year | 2019 |
| Title | LncRNA RGMB-AS1 Promotes Glioma Growth and Invasion Through miR-1200/HOXB2 Axis |
External Links
| Links for RGMB-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |