Basic Information
| LncRNA/CircRNA Name | RGMB-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:98769618-98773469 |
| Ensemble | ENSG00000246763 |
| Refseq | NR_033932 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | LSCC tissues and adjacent non-tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA RGMB-AS1 was shown to be upregulated in LSCC tissues. High RGMB-AS1 expression was closely associated with advanced clinical features and poor prognosis. Silencing of lncRNA RGMB-AS1 suppressed LSCC cells proliferation and invasion in vitro and inhibited tumor growth in vivo. In mechanism, lncRNA RGMB-AS1 could sponge miR-22 to upregulate the expression of NLRP3. Additionally, we verified that the suppression of LSCC progression induced by lncRNA RGMB-AS1 reduction required the activity of miR-22. |
| Pubmed ID | 31351424 |
| Year | 2019 |
| Title | LncRNA RGMB-AS1 promotes laryngeal squamous cell carcinoma cells progression via sponging miR-22/NLRP3 axis |
External Links
| Links for RGMB-AS1 | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |