Basic Information
| LncRNA/CircRNA Name | RHPN1-AS1 |
| Synonyms | RHPN1-AS1, C8orf51 |
| Region | GRCh38_8:143366631-143368548 |
| Ensemble | ENSG00000254389 |
| Refseq | NR_026785 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | qPCR, Western blot, RNAi, other |
| Sample | HNSCC tissues and cell lines (Cal-27, Tca8113) |
| Expression Pattern | up-regulated |
| Function Description | RHPN1-AS1 was upregulated in HNSCC tissues and that its expression level was associated with neoplasm histologic grade. High expression of RHPN1-AS1 was also confirmed in HNSCC tissues. Knockdown of RHPN1-AS1 inhibited tumor cell migration, invasion and proliferation in HNSCC. Furthermore, inhibition of RHPN1-AS1 suppressed the expression of epithelial-mesenchymal transition (EMT)-related genes (?-Catenin, Claudin-1 and Vimentin) in HNSCC cells. |
| Pubmed ID | 31417644 |
| Year | 2019 |
| Title | Knockdown of LncRNA RHPN1-AS1 Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma |
External Links
| Links for RHPN1-AS1 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |