Basic Information
| LncRNA/CircRNA Name | RMRP |
| Synonyms | NA |
| Region | GRCh38_9:35657751-35658018 |
| Ensemble | ENSG00000277027 |
| Refseq | NR_003051 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Luciferase reporter assay etc. |
| Sample | HCC tumor tissues and adjacent normal tissues ,HCC cell lines (Hep3B, HepG2, MHCC97H and HuH7) and human hepatic cell line HL-7702 (L02) |
| Expression Pattern | down-regulated |
| Function Description | MRP was down-regulated in HCC tissues and cells. Low expression of RMRP was correlated with poor survival of HCC patients. The A495 value and colony number were significantly decreased in pcDNA3.1-RMRP-transfected MHCC97H and HuH7 cells. The apoptosis rate was significantly increased in pcDNA3.1-RMRP-transfected MHCC97H and HuH7 cells. |
| Pubmed ID | 32308432 |
| Year | 2020 |
| Title | Long Noncoding RNA RMRP Suppresses the Tumorigenesis of Hepatocellular Carcinoma Through Targeting microRNA-766. |
External Links
| Links for RMRP | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |