Basic Information
| LncRNA/CircRNA Name | RMRP |
| Synonyms | NA |
| Region | GRCh38_9:35657751-35658018 |
| Ensemble | ENSG00000277027 |
| Refseq | NR_003051 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | NSCLC and adjacent nontumor tissues ,lung adenocarcinoma cell lines(A549, Calu1, H1299,H460),human lung epithelial cell line (BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | RMRP was elevated in NSCLC tissues and cell lines. High RMRP expression was closely associated with advanced stage for the clinical features and low overall survival in NSCLC patients.Loss of RMRP markedly inhibited cell proliferation, migration, and invasion.Moreover, the role of RMRP on NSCLC cell progression was modulated by the inhibition of miR-1-3p. |
| Pubmed ID | 31050363 |
| Year | 2019 |
| Title | Long Noncoding RNA RMRP Promotes Proliferation and Invasion via Targeting miR-1-3p in Non-Small-Cell Lung Cancer |
External Links
| Links for RMRP | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |