Basic Information
| LncRNA/CircRNA Name | RMRP |
| Synonyms | NA |
| Region | GRCh38_9:35657751-35658018 |
| Ensemble | ENSG00000277027 |
| Refseq | NR_003051 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | PTC and adjacent normal tissues?,PTC cell lines (HTH83, BCPAP, and TPC-1) and normal human thyroid cell line (HT-ori3) |
| Expression Pattern | up-regulated |
| Function Description | The expression of RMRP was found to be elevated in PTC tissues, compared with adjacent normal tissues. Furthermore, RMRP expression was inversely correlated with miR-675 expression in PTC tissues. miR-675 expression was decreased in PTC tissues and cell lines. A low level of miR-675 expression was significantly correlated with lymphatic metastasis and TNM stage in PTC patients.Ectopic miR-675 expression suppressed PTC cell proliferation, migration, and invasion in vitro and hindered tumor growth in vivo.RMRP functioned as a ceRNA of miR-675 in PTC cells. Silencing RMRP expression inhibited the growth and metastasis of PTC cells by sponging miR-675 and regulating MAPK1. |
| Pubmed ID | 31564913 |
| Year | 2019 |
| Title | MicroRNA-675 Directly Targets MAPK1 to Suppress the Oncogenicity of Papillary Thyroid Cancer and Is Sponged by Long Non-Coding RNA RMRP |
External Links
| Links for RMRP | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |