Basic Information
| LncRNA/CircRNA Name | RMST |
| Synonyms | NCRMS, RMST, LINC00054, NCRMS, NCRNA00054 |
| Region | GRCh38_12:97430884-97598415 |
| Ensemble | ENSG00000255794 |
| Refseq | NR_024037 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, mMicroarray |
| Sample | breast cancer tissue, cells lines (MCF7, AU565, BT-20, BT-549, MCF-10A, HEK-239, MB231, MB468) |
| Expression Pattern | down-regulated |
| Function Description | RMST played its biological function through regulating the mRNA or protein expression in cytoplasm.RMST could slow down the proliferation of TNBC cells to influence the tumor progression.RMST could enhance cell apoptosis in TNBC. The cell cycle detected by FCM assay indicated that RMST might induce the block of G0/G1 phase thus inhibiting TNBC cell proliferation.RMST overexpression could also restrain the invasion and migration abilities of TNBC cells. |
| Pubmed ID | 29215701 |
| Year | 2017 |
| Title | Long non-coding RNA (LncRNA) RMST in triple-negative breast cancer (TNBC):Expression analysis and biological roles research. |
External Links
| Links for RMST | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |