Basic Information
| LncRNA/CircRNA Name | RNCR3 |
| Synonyms | LINC00599 |
| Region | GRCh38_8:9900064-9905366 |
| Ensemble | ENSG00000253230 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | colorectal cancer tissues,cell lines (NCM460, HCT116, SW480, Caco-2, PKR) |
| Expression Pattern | up-regulated |
| Function Description | RNCR3 was elevated in colorectal cancer, and it was negatively correlated with expression of miR-1301-3p which was decreased in cancers. Then, RNCR3 could interact with and suppress miR-1301-3p expression in HCT116 and SW480. Knockdown of RNCR3 or miR-1301-3p overexpression significantly inhibited cell growth, invasion, and increased apoptosis through suppressing expression of Cyclin A1, PCNA, N-cadherin, Bcl-2, and promoting expression of E-cadherin, Bax in vitro and in vivo. RUNX1 was directly bound to RNCR3 promoter to activate RNCR3 expression. |
| Pubmed ID | 32239427 |
| Year | 2020 |
| Title | RUNX1-activated Upregulation of lncRNA RNCR3 Promotes Cell Proliferation, Invasion, and Suppresses Apoptosis in Colorectal Cancer via miR-1301-3p/AKT1 Axis in Vitro and in Vivo |
External Links
| Links for RNCR3 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |