Basic Information
| LncRNA/CircRNA Name | ROPNR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, ChIP etc. |
| Sample | bone marrow, cell lines (KG-1, KG-1a, Kasumi-1, K562) |
| Expression Pattern | up-regulated |
| Function Description | We describe a RUNX1-intragenic long noncoding RNA ROPNR that is transcribed as unspliced transcript from an upstream overlapping promoter. ROPNR was upregulated in AML samples and in response to Ara-C treatment in vitro. ROPNR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancers and participates in the orchestration of an intrachromosomal loop. The 3' region of ROPNR also participates in long-range interchromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations. |
| Pubmed ID | 24752773 |
| Year | 2014 |
| Title | An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies. |
External Links
| Links for ROPNR | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |