Basic Information
| LncRNA/CircRNA Name | ROR1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:64094442-64171297 |
| Ensemble | ENSG00000223949 |
| Refseq | NR_110665 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, Western blot, RIP |
| Sample | LAC tissues,cell lines (SPCA1, H1299, A549, and H358) |
| Expression Pattern | up-regulated |
| Function Description | ROR1-AS1 expression level was significantly higher in LAC samples compared with that in adjacent tissues, which was associated with patients??prognosis. ROR1-AS1 could act as a sponge for miR-375 and promo//e cell migration and invasion through suppressing the process of EMT in LAC, which may offer a potential therapeutic target in LAC. |
| Pubmed ID | 31983094 |
| Year | 2019 |
| Title | Long noncoding RNA ROR1-AS1 enhances lung adenocarcinoma metastasis and induces epithelial-mesenchymal transition by sponging miR-375 |
External Links
| Links for ROR1-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |