Basic Information
| LncRNA/CircRNA Name | ROR1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:64094442-64171297 |
| Ensemble | ENSG00000223949 |
| Refseq | NR_110665 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | CRC tissues, CRC cell lines (HCT116, HT29, SW620 and SW480) and normal human colonic epithelial cell line (NCM460) |
| Expression Pattern | up-regulated |
| Function Description | By comparison with ROR1-AS1 expression in adjacent tissues, the ROR1-AS1 expression level was significantly higher in CRC samples. Moreover, loss of ROR1-AS1 inhibited cell migration and cell invasion of CRC cells. Besides, gain of ROR1-AS1 enhanced cell migration and cell invasion of CRC cells. Furthermore, it was found that ROR1-AS1 acted as a competing endogenous RNA via sponging miR375 in CRC. |
| Pubmed ID | 31486489 |
| Year | 2019 |
| Title | Long non-coding RNA ROR1-AS1 enhances colorectal cancer metastasis by targeting miR-375 |
External Links
| Links for ROR1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |