Basic Information
| LncRNA/CircRNA Name | ROR1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:64094442-64171297 |
| Ensemble | ENSG00000223949 |
| Refseq | NR_110665 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | CRC cell lines (HCT116, HT29, SW620, SW480) and normal human colonic epithelial cell line (NCM460), CRC tissues, adjacent normal tissues, CRC tissues, adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | Detection of ROR1-AS1 expression level in patients` tissues showed that ROR1- AS1 was higher in CRC tissues than that in adjacent ones. ROR1-AS1 expression was negatively associated with patients` overall survival time. Cell growth ability was inhibited due to knockdown of ROR1-AS1 in vitro. Moreover, cell migration and invasion abilities were repressed after ROR1-AS1 was knockdown. Furthermore, due to the knockdown of ROR1-AS1, the targeted proteins in Wnt/?-catenin signaling pathway were suppressed. |
| Pubmed ID | 31389604 |
| Year | 2019 |
| Title | ROR1-AS1 promotes tumorigenesis of colorectal cancer via targeting Wnt/?-catenin |
External Links
| Links for ROR1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |