Basic Information
| LncRNA/CircRNA Name | RP11-137H2.4 |
| Synonyms | RP11-137H2.4, LOC101929574 |
| Region | GRCh38_10:80529597-80535942 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | childhood acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Cell proliferation assay etc. |
| Sample | cell lines (Reh, NALM-6) |
| Expression Pattern | up-regulated |
| Function Description | Here we report five lncRNAs specifically upregulated in pre-B cALL that had significant impacts on cancer hallmark traits such as cell proliferation, migration, apoptosis, and treatment response. In particular, silencing of the RP11-137H2.4 lncRNA effectively restored normal glucocorticoid (GC) response in a GC-resistant pre-B cALL cell line and specifically modulated expression of members of both the NRAS/BRAF/NF-kB MAPK cascade and cell cycle pathways. |
| Pubmed ID | 27980230 |
| Year | 2017 |
| Title | A childhood acute lymphoblastic leukemia-specific lncRNA implicated in prednisolone resistance, cell proliferation, and migration. |
External Links
| Links for RP11-137H2.4 | GenBank HGNC NONCODE |
| Links for childhood acute lymphoblastic leukemia | OMIM COSMIC |