Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | bladder cancer-associated transcript 1 |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR, Luciferase Reporter Assay, Western blot Assay |
| Sample | OSCC cell lines SCC9, CAL-27 and FaDu,OECM-1,and normal oral keratinocyte (NOK) |
| Expression Pattern | up-regulated |
| Function Description | The expression of BLACAT1 was increased and the expression of miR-142-5p was decreased in OSCC cells. The knockdown of BLACAT1 suppressed the viability, migration and invasion of OSCC cells. miR-142-5p was identified as a target of BLACAT1 and BLACAT1 overexpression suppressed miR-142-5p expression. |
| Pubmed ID | 31841186 |
| Year | 2019 |
| Title | LncRNA BLACAT1 Regulates the Viability, Migration and Invasion of Oral Squamous Cell Carcinoma Cells by Targeting miR-142-5p |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |