Basic Information
| LncRNA/CircRNA Name | RP11-169D4.1 |
| Synonyms | RP11-169D4.2 |
| Region | GRCh38_11:72570660-72573229 |
| Ensemble | ENSG00000227467 |
| Refseq | NR_126364 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qPCR, Western blot etc. |
| Sample | laryngeal squamous cell carcinoma tissues, cell lines (SNU899 and SNU46) |
| Expression Pattern | down-regulated |
| Function Description | RP11-169D4.1 expression was markedly decreased in LSCC tissues and cell lines.The overexpression of RP11-169D4.1 inhibited the proliferation, migration and invasion of LSCC cell lines as well as promoted apoptosis.We further verified that miR-205-5p had binding sites with RP11-169D4.1 and that RP11-169D4.1 could regulate the expression of CDH1.Ectopic transfection of RP11-169D4.1 led to a significant reduction in the downstream signaling molecule AKT in LSCC cells. The long non-coding RNA RP11-169D4.1 may serve as a tumor suppressor and a promising therapeutic target in laryngeal cancer,which could inhibit the process of EMT by regulating CDH1. |
| Pubmed ID | 28534968 |
| Year | 2018 |
| Title | Functional significance of the long non-coding RNA RP11-169D4.1 as a metastasis suppressor in laryngeal squamous cell carcinoma by regulating CDH1. |
External Links
| Links for RP11-169D4.1 | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |