Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | NA |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay etc. |
| Sample | HCC cell lines(HeG2, MHCC97 L, HuH7, Hep3B, SK-HEP-1, SNU-449, SNU-182, SNU- 429 and bel-7402) ,Non- tumorigenic liver epithelial cell lines( THLE2 and THLE3) ,HCC tumors tissues and adjacent normal (non-tumorigenic) tissues |
| Expression Pattern | up-regulated |
| Function Description | BLACAT1 was found to be overexpressed in both HCC cells and human HCC tumors.Ientivirus-induced BLACAT1 downregulation inhibited cancer cellin vitro proliferation and invasion, and in vivo xenograft growth.Has-miR-485-5p was confirmed to be bound by BLACAT1 and its expression in HCC cells inversely regulated by BLACAT1. Then, has-miR-485-5p downregulation reversed the inhibitory effects of BLACAT1 downregulation on HCC cancer cell in vitro functions. |
| Pubmed ID | 31174090 |
| Year | 2019 |
| Title | Long Noncoding RNA BLACAT1 Is Overexpressed in Hepatocellular Carcinoma and Its Downregulation Suppressed Cancer Cell Development Through Endogenously Competing Against hsa-miR-485-5p |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |