Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | LINC00912, linc-UBC1, onco-lncRNA-30 |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, RNAi, RIP, Western blot, other |
| Sample | NSCLC tissues and DDP-sensitive cell lines (A549 and H1299) and DDP-resistant cell lines (A549/DDP) and H1299/DDP) |
| Expression Pattern | up-regulated |
| Function Description | Compared with in DDP-sensitive NSCLC cells, expression of BLACAT1, ATG7, MRP1, LC3-II/LC3-I and Beclin 1 was significantly upregulated in DDP-resistant NSCLC cells, whereas miR-17 was downregulated in DDP-resistant NSCLC cells. Short interfering RNA against BLACAT1 decreased the viability of DDP-resistant NSCLC cells. In addition, BLACAT1 interacted with miR-17, and negatively regulated miR-17. BLACAT1 promoted ATG7 expression through miR-17, and facilitated autophagy and promoted chemoresistance of NSCLC cells through miR-17/ATG7. Finally, in vivo experiments indicated that inhibition of BLACAT1 ameliorated the chemoresistance of NSCLC. |
| Pubmed ID | 30387831 |
| Year | 2019 |
| Title | LncRNA BLACAT1 is involved in chemoresistance of non-small cell lung cancer cells by regulating autophagy. |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |