Basic Information
| LncRNA/CircRNA Name | RP11-476D10.1 |
| Synonyms | NA |
| Region | GRCh38_12:40140926-40142876 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | RT-qPCR, RIP, Western blot analysis etc. |
| Sample | PTC cell line TPC-1 |
| Expression Pattern | up-regulated |
| Function Description | Initially, RP11-476D10.1 and LRRK2 were highly expressed in PTC cells. Meanwhile, miR-138-5p was confirmed to bind with lncRNA RP11-476D10.1 and LRRK2. RP11-476D10.1 downregulated the miR-138-5p expression, thereby upregulating the LRRK2 expression.The results showed that silenced lncRNA RP11-476D10.1 or overexpressed miR-138-5p enhanced the apoptosis and autophagy of PTC cells while reducing cell proliferation, with increased levels of Bax, LC3B, and Beclin1 and decreased Bcl-2 level were observed. |
| Pubmed ID | 31102261 |
| Year | 2019 |
| Title | Silencing of Long Noncoding RNA RP11-476D10.1 Enhances Apoptosis and Autophagy While Inhibiting Proliferation of Papillary Thyroid Carcinoma Cells via microRNA-138-5p-dependent Inhibition of LRRK2 |
External Links
| Links for RP11-476D10.1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |