Basic Information
| LncRNA/CircRNA Name | RP11-547D24.1 |
| Synonyms | NA |
| Region | GRCh38_1:2013213-2015530 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | PTC tissues and paired adjacent noncancerous thyroid tissues ,human cell lines(NTHY, TPC-1, and K1) |
| Expression Pattern | up-regulated |
| Function Description | The frequent upregulation of RP11-547D24.1 in PTC tissues suggests that RP11-547D24.1 is significantly related to PTC tumorigenesis.Depletion of RP11-547D24.1 resulted in G0/G1 phase cells significant increases and S phase cells arrest in TPC-1 cells.The proportion of apoptotic PTC cells was markedly increased by RP11-547D24.1 knockdown, and the migration capacity was suppressed by silencing RP11-547D24.1 in PTC cells.RP11-547D24.1 over-expression significantly promoted the invasion of PTC cells in vitro.RP11-547D24.1 knockdown reduced the levels of PAX8/PPARG, NOTCH4, FZD4, FGFR2 and FLF4.RP11-547D24.1 promotes the growth and metastasis of PTC cells in vitro and may be related to the PPAR, VEGF, Wnt, MAPK, and Notch signaling pathways. |
| Pubmed ID | 31044550 |
| Year | 2019 |
| Title | RP11-547D24.1 Regulates Proliferation and Migration in Papillary Thyroid Carcinoma: Identification and Validation of a Novel Long Noncoding RNA Through Integrated Analysis of TCGA Database |
External Links
| Links for RP11-547D24.1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |