Basic Information
| LncRNA/CircRNA Name | RP11-81H3.2 |
| Synonyms | NA |
| Region | GRCh38_12:74133166-74402535 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blotting, Luciferase Reporter Assay |
| Sample | tumor samples and adjacent tissues,HepG2, Smmc-7721, and Huh7 cells |
| Expression Pattern | up-regulated |
| Function Description | RP11-81H3.2, which is enriched in HCC and can promote its proliferation, migration, and invasion both in vitro and in vivo. In addition, our results showed that RP11-81H3.2 binds to and regulate miR-490-3p expression in the HCC cells. Moreover, we found that RP11-81H3.2 regulates the expression of TNKS2 via miR-490-3p. Further, we found that RP11-81H3.2 and miR-490-3p form a regulatory loop; the release of RP11-81H3.2 leads to the suppression of miR-490-3p expression, thus, further enhancing the expression of RP11-81H3.2. |
| Pubmed ID | 31858324 |
| Year | 2019 |
| Title | RP11-81H3.2 Acts as an Oncogene via microRNA-490-3p Inhibition and Consequential Tankyrase 2 Up-Regulation in Hepatocellular Carcinoma |
External Links
| Links for RP11-81H3.2 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |