Basic Information
| LncRNA/CircRNA Name | RP4 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Western blot, qPCR, in vitro knockdown etc. |
| Sample | cell line (SW480) |
| Expression Pattern | down-regulated |
| Function Description | Cell proliferation,tumor growth,and early apoptosis in SW480 cells were negatively regulated by lncRNA RP4.Functional experiments indicated that lncRNA RP4 directly upregulated SH3GLB1 expression by acting as a competing endogenous RNA (ceRNA) for miR-7-5p. This interaction led to activation of the autophagy-mediated cell death pathway and de-repression of PI3K and Akt phosphorylation in colorectal cancer cells in vivo. |
| Pubmed ID | 29531464 |
| Year | 2018 |
| Title | Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer. |
External Links
| Links for RP4 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |