Basic Information
| LncRNA/CircRNA Name | RP5-1024C24.1 |
| Synonyms | NA |
| Region | GRCh38_11:30584130-30630508 |
| Ensemble | ENSG00000254489 |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | papillary thyroid cancer tissues, cell lines (TPC-1 and FRO) |
| Expression Pattern | down-regulated |
| Function Description | RP5-1024C24.1 are down-regulated in benign and malignant thyroid neoplasias. The restoration of RP5-1024C24.1 expression in thyroid carcinoma cell lines reduced cell proliferation and migration by modulating the PTEN/Akt pathway. Inhibition of thyroid carcinoma cell growth and cell migration ability was also achieved by the MPPED2 restoration. Interestingly, RP5-1024C24.1 over-expression is able to increase MPPED2 expression. |
| Pubmed ID | 29783666 |
| Year | 2018 |
| Title | The Long Non-Coding RNA RP5-1024C24.1 and Its Associated-Gene MPPED2 Are Down-Regulated in Human Thyroid Neoplasias and Act as Tumour Suppressors |
External Links
| Links for RP5-1024C24.1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |