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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown
Sample	The human HCC cell lines HepG2, Smmc-7721 and Huh7, HCC clinical samples and para-carcinoma tissues
Expression Pattern	up-regulated
Function Description	we identified a novel long non-coding RNA, RP5-1120P11.3 that ectopically expressed in HCC. Further characterization of RP5-1120P11.3 revealed that RP5-1120P11.3 promoted proliferation and invasion of HCC while inhibited apoptosis. Importantly, our data revealed that miR-196b-5p interacted with and was regulated by RP5-1120P11.3 via a sponging mechanism. Inhibition of miR-196b-5p attenuated the phenotypes resulted from RP5-1120P11.3 inhibition. Moreover, our data showed that miR-196b-5p inhibited the expression of WIPF2 in HCC and thus illustrated a regulatory axis of RP5-1120P11.3/miR-196b-5p/WIPF2 that facilitated the progression of HCC. In addition, our data showed that RP5-1120P11.3 contributed to the xenograft generation in vivo via regulating miR-196b-5p and WIPF2.
Pubmed ID	31299165
Year	2019
Title	RP5-1120P11.3 promotes hepatocellular carcinoma development via hsa-miR-196b-5p/WIPF2 axis

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