Basic Information
| LncRNA/CircRNA Name | RSU1P2 |
| Synonyms | RSU1P2 |
| Region | GRCh38_10:45099487-45154596 |
| Ensemble | ENSG00000232554 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Flow cytometry assay, Cell migration and invasion assay etc. |
| Sample | cervical cancer tissues, cell lines (SMMC-7721 and HepG3) |
| Expression Pattern | up-regulated |
| Function Description | Here, we found that the lncRNA RSU1P2 is upregulateded in cervical cancer tissues and has a tumour-promoting role. We revealed that RSU1P2 acts as a ceRNA through regulating the expression of IGF1R, N-myc and EphA4. The mechanism of this regulation is via competition for the shared microRNA let-7a. This competition promotes the malignant phenotype of cervical carcinoma cells. The transcription factor N-myc forms a positive feedback loop with RSU1P2 by in turn activating its expression, thereby enhancing its oncogenic capacity. |
| Pubmed ID | 27487126 |
| Year | 2016 |
| Title | LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells. |
External Links
| Links for RSU1P2 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |