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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	qPCR, Western blot, in vitro knockdown, etc.
Sample	CRC tissues, human CRC cell lines (HCT116, HT29, RKO, SW620, and SW480) and normal colonic epithelial cell line (FHC)
Expression Pattern	down-regulated
Function Description	Significant down regulation of lncRNA RUNX1 IT1 was measured in CRC tissues and three CRC cell lines (HCT116, HT29, and RKO) compared with paired nontumorous adjacent tissues (P < 0.01) or the normal colonic epithelial cell line FHC (P < 0.05), respectively. Moreover, the proliferative and migration potential of CRC cells were inhibited by overexpressing lncRNA RUNX1 IT1, which could be obviously improved by knocking down lncRNA RUNX1 IT1. The protein levels of PCNA, Ki67, and MMP9 were upregulated by overexpressing lncRNA RUNX1 IT1 and down regulated in si RUNX1 IT1 cells. Besides, lncRNA RUNX1 IT1 could also promote the apoptosis of CRC cells. In conclusion, lncRNA RUNX1 IT1 is downregulated in CRC and plays a tumour suppressive role due to the regulatory of cell proliferation, migration, and apoptosis.
Pubmed ID	30499136
Year	2018
Title	Long non-coding RNA RUNX1-IT1 plays a tumour-suppressive role in colorectal cancer by inhibiting cell proliferation and migration

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