Basic Information
| LncRNA/CircRNA Name | SATB2-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:199457700-199476935 |
| Ensemble | ENSG00000225953 |
| Refseq | NR_026830 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RIP, etc. |
| Sample | CRC tissues, CRC cell lines (HCT-116, HT-29, SW-620, HCT-8, SW-480, and DLD-1), normal colorectal epithelial cell line NCM460 |
| Expression Pattern | down-regulated |
| Function Description | SATB2-AS1 is specifically expressed in colorectal tissues and downregulated in CRC. Survival analysis indicates that decreased SATB2-AS1 expression is associated with poor survival. Functional experiments and bioinformatics analysis revealed that SATB2-AS1 inhibits CRC cell metastasis and regulates TH1-type chemokines expression and immune cell density in CRC. Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2. |
| Pubmed ID | 31492160 |
| Year | 2019 |
| Title | LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2 |
External Links
| Links for SATB2-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |