Basic Information
| LncRNA/CircRNA Name | SBF2-AS1 |
| Synonyms | NA |
| Region | GRCh38_11:9758292-9811319 |
| Ensemble | ENSG00000246273 |
| Refseq | NR_036485 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | PC cell lines (PANC-1, BxPC-3, SW1990, Capan-2) and human mononuclear macrophage cell line (THP-1) |
| Expression Pattern | differential expressed |
| Function Description | Overexpressed lncRNA SBF2-AS1 promoted progression of PC cells. LncRNA SBF2-AS1 was found to act as a competing endogenous RNA to repress miR-122-5p and up-regulate XIAP. Constrained lncRNA SBF2-AS1 in M2 macrophage-derived exosomes contributed to restraining tumorigenic ability of PC cells. |
| Pubmed ID | 32301277 |
| Year | 2020 |
| Title | Down-regulated lncRNA SBF2-AS1 in M2 macrophage-derived exosomes elevates miR-122-5p to restrict XIAP, thereby limiting pancreatic cancer development. |
External Links
| Links for SBF2-AS1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |