Basic Information
| LncRNA/CircRNA Name | SBF2-AS1 |
| Synonyms | NA |
| Region | GRCh38_11:9758292-9811319 |
| Ensemble | ENSG00000246273 |
| Refseq | NR_036485 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | ESCC tissues,cell lines(Eca-109, KYSE-150, TE-1,KYSE-140) |
| Expression Pattern | up-regulated |
| Function Description | In the present research, we found that the expression of SBF2-AS1 and PFN2 was up-regulated, while miR-494 was down-regulated in ESCC tumors and cells using quantitative real-time polymerase chain reaction (qRT-PCR).SBF2-AS1 contributed to cell proliferation, migration, invasion and EMT in ESCC by enhancing PFN2 expression via sponging miR-494, providing promising biomarkers for ESCC diagnosis and treatment. |
| Pubmed ID | 32229486 |
| Year | 2020 |
| Title | Overexpression of Long Non-Coding RNA SBF2-AS1 Promotes Cell Progression in Esophageal Squamous Cell Carcinoma (ESCC) by Repressing miR-494 to Up-Regulate PFN2 Expression |
External Links
| Links for SBF2-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |