Basic Information
| LncRNA/CircRNA Name | SBF2-AS1 |
| Synonyms | NA |
| Region | GRCh38_11:9758292-9811319 |
| Ensemble | ENSG00000246273 |
| Refseq | NR_036485 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, other |
| Sample | HCC tissues and cell lines (HCCLM3, Huh7, SK-Hep1, HepG2) |
| Expression Pattern | up-regulated |
| Function Description | In addition, high SBF2-AS1 expression levels were correlated with vein invasion (p = 0.008) and TNM stage (p = 0.013). Furthermore, Kaplan-Meier survival analysis indicated that high expressions of SBF2-AS1 were correlated with shorter overall survival of HCC patients. Univariate and multivariate analysis identified high SBF2-AS1 expression as an unfavorable prognostic factor for overall survival. Further functional analysis demonstrated that knockdown of SBF2-AS1 significantly inhibited HCC cells proliferation, migration and invasion. Mechanistically, we found that SBF2-AS1 could promote the activation of EMT pathway, which was demonstrated by measuring the expression levels of EMT-related markers. |
| Pubmed ID | 30338801 |
| Year | 2018 |
| Title | LncRNA SBF2-AS1 Promotes Hepatocellular Carcinoma Metastasis by Regulating EMT and Predicts Unfavorable Prognosis |
External Links
| Links for SBF2-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |