Basic Information
| LncRNA/CircRNA Name | SChLAP1 |
| Synonyms | NA |
| Region | GRCh38_2:180692104-180916939 |
| Ensemble | ENSG00000281131 |
| Refseq | NR_104323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | primary glioma tissue, glioblastoma cell lines (U118MG and LN229) and the human embryonic kidney cell line 293 (HEK293) |
| Expression Pattern | up-regulated |
| Function Description | SChLAP1 was increased in primary GBM samples and cell lines, and knockdown of the lncRNA suppressed growth. SChLAP1 was found to bind heterogeneous nuclear ribonucleoprotein L (HNRNPL) which stabilized the lncRNA and led to an enhanced interaction with the protein actinin alpha 4 (ACTN4). ACTN4 was also highly expressed in primary GBM samples and was associated with poorer overall survival in glioma patients. The SChLAP1-HNRNPL complex led to stabilization of ACTN4 through suppression of proteasomal degradation, which resulted in increased nuclear localization of the p65 subunit of NF-?B and activation of NF-?B signaling, a pathway associated with cancer development. |
| Pubmed ID | 31492748 |
| Year | 2019 |
| Title | Long noncoding RNA SChLAP1 forms a growth promoting complex with HNRNPL in human glioblastoma through stabilization of ACTN4 and activation of NF-?B signaling |
External Links
| Links for SChLAP1 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |