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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qPCR, Western blot
Sample	SNU-398 and SNU-182 HCC cell lines, liver biopsy 73 to collect cancer (HCC) and adjacent (2 cm around tumors) non-cancer tissues
Expression Pattern	down-regulated
Function Description	SEMA3B-AS1 was downregulated in 17 HCC tissues comparing to non-cancer tissues and was not affected by HBV and HCV 18 infections. In addition, SEMA3B-AS1 expression was not affect by cancer 19 development and low SEMA3B-AS1 levels were closely correlated with poor 20 survival. SEMA3B-AS1 in HCC tissues was inversely correlated with miR-718 and 21 positively correlated with PTEN. In HCC cells, SEMA3B-AS1 overexpression 22 resulted in upregulated, while miR-718 overexpression resulted in downregulated 23 PTEN expression. In addition, miR-718 overexpression attenuated the effects of 24 SEMA3B-AS1 overexpression. SEMA3B-AS1 and PTEN overexpression resulted in 25 reduced, while miR-718 overexpression resulted in increased proliferation rate of 26 HCC cells. In addition, miR-718 overexpression attenuated the effects of SEMA3B27 AS1 overexpression.
Pubmed ID	31251699
Year	2019
Title	MiR-718 mediates the indirect interaction between lncRNA SEMA3B-AS1 and 2 PTEN to regulate the proliferation of hepatocellular carcinoma cells

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