Basic Information
| LncRNA/CircRNA Name | Skp2 |
| Synonyms | SKP2, FBL1, FBXL1, FLB1, p45 |
| Region | GRCh38_5:36151989-36184319 |
| Ensemble | ENSG00000145604 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc. |
| Sample | NSCLC tissues, NSCLC cell lines (ATCC, Rockville, MD, USA) |
| Expression Pattern | differential expression |
| Function Description | These data suggest that the Skp2 may be regulated by Meg3 at post-transcriptional level. Bioinformatics analyses showed that miR-3163 bound to 3'-UTR of Skp2 mRNA in NSCLC cells to inhibit its translation, which was supported by luciferase reporter assay. Meg3 augmented the effects of miR-3163 on Skp2 mRNA, possibly through binding-induced function enhancement, which was supported by the double fluorescent in situ hybridization showing co-localized intracellular Meg3 and miR-3163 signals in NSCLC cells. The miR-3163 levels in NSCLC were not different from in NT, suggesting that the regulation of Skp2 in NSCLC by miR-3163 may require coordination of Meg3 |
| Pubmed ID | 26482610 |
| Year | 2015 |
| Title | Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163 |
External Links
| Links for Skp2 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |