Basic Information
| LncRNA/CircRNA Name | SLC7A11-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:138057464-138178177 |
| Ensemble | ENSG00000250033 |
| Refseq | NR_038380 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qRT-PCR, Western blot, RIP |
| Sample | PDAC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | SLC7A11-AS1 is overex-pressed in PDAC tissues and gemcitabine-resistant cell lines. Knockdown of SLC7A11-AS1 weakens the PDAC stemness and potentiates the sensitivity of resistant PDAC cells toward gemcitabine in vitro and in vivo. |
| Pubmed ID | 32036249 |
| Year | 2020 |
| Title | lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCF b-TRCP -Mediated Degradation of NRF2 in Pancreatic Cancer |
External Links
| Links for SLC7A11-AS1 | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |