Basic Information
| LncRNA/CircRNA Name | SLCO4A1-AS1 |
| Synonyms | NA |
| Region | GRCh38_20:62663019-62666724 |
| Ensemble | ENSG00000232803 |
| Refseq | NR_024470 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, RIP, other |
| Sample | CRC tissues and cell lines (HCT116, HCT8, HT29, SW480, LOVO and SW620) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA SLCO4A1-AS1 was significantly upregulated in CRC tissues and its overexpression was closely related with poor prognosis and tumor metastasis. By knocking down SLCO4A1-AS1, we found that SLCO4A1-AS1 promoted the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of CRC cells in vitro, as well as inhibited cell apoptosis. Moreover, SLCO4A1-AS1 dramatically delayed tumor propagation in vivo. Mechanistically, SLCO4A1-AS1 activates Wnt/?-catenin signaling. SLCO4A1-AS1 enhanced the stability of ?-catenin by impairing the interaction of ?-catenin with GSK? and inhibiting its phosphorylation. Finally, restoration of ?-catenin protein level rescued the proliferation, migration and invasion in SLCO4A1-AS1-depleted CRC cells. |
| Pubmed ID | 30201010 |
| Year | 2018 |
| Title | LncRNA SLCO4A1-AS1 Facilitates Growth and Metastasis of Colorectal Cancer Through ?-Catenin-Dependent Wnt Pathway |
External Links
| Links for SLCO4A1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |