Basic Information
| LncRNA/CircRNA Name | SMAD5-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:136129507-136134890 |
| Ensemble | ENSG00000164621 |
| Refseq | NR_026763 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | diffuse large B-cell lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | DLBCL tissues,cell lines (TMD8,HEK-293,GM12878,L428,OCI-Ly3,U2932) |
| Expression Pattern | up-regulated |
| Function Description | while the up-regulation of SMAD5-AS1 expression could reverse the enhancement of the transcriptional activity of TOP/FOP caused by miR-135b-5p mimic |
| Pubmed ID | 30874550 |
| Year | 2019 |
| Title | Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/?-catenin pathway by sponging miR-135b-5p to elevate expression of APC. |
External Links
| Links for SMAD5-AS1 | GenBank HGNC NONCODE |
| Links for diffuse large B-cell lymphoma | OMIM COSMIC |