Basic Information
| LncRNA/CircRNA Name | SMAD5-AS1 |
| Synonyms | SMAD5 antisense RNA 1 |
| Region | GRCh38_5:136129507-136134890 |
| Ensemble | ENSG00000164621 |
| Refseq | NR_026763 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | RT-qPCR, Dual Luciferase Reporter Gene Assay, RIP, Western blot analysis |
| Sample | NPC tissues,The 5-8F NPC cell line with high tumorigenicity and high metastatic potential, 6-10B NPC cell line without metastatic potential, highly differentiated nasopharyngeal squamous carcinoma cell line CNE-1, poorly differentiated nasopharyngeal squamous carcinoma cell lines CNE-2 and HONE-1, and immortalized nasopharyngeal epithelial cells NP69 |
| Expression Pattern | up-regulated |
| Function Description | High expression of SMAD5-AS1 and SMAD5 but low miR-195 expression was determined in NPC tissues and NPC cell lines.Downregulation of SMAD5-AS1 or SMAD5 or overexpression of miR-195 led to inhibited NPC cell proliferation, invasion and migration and reversed EMT, enhanced apoptosis in vitro as well as restrained tumor growth in vivo. |
| Pubmed ID | 31921616 |
| Year | 2019 |
| Title | Silencing of Long Non-coding RNA SMAD5-AS1 Reverses Epithelial Mesenchymal Transition in Nasopharyngeal Carcinoma via microRNA-195-Dependent Inhibition of SMAD5 |
External Links
| Links for SMAD5-AS1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |