Basic Information
| LncRNA/CircRNA Name | BRE-AS1 |
| Synonyms | BABAM2-AS1 |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_028308 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP, RNAi, other |
| Sample | NSCLC tissues and cell lines (A549, H1563, H1975, and H1299) |
| Expression Pattern | down-regulated |
| Function Description | Gain-of-function and loss-of-function assays showed that BRE-AS1 reduces NSCLC cell viability, represses NSCLC cell proliferation, and induces NSCLC cell apoptosis in vitro, and represses NSCLC tumor growth in vivo. Mechanistic investigation revealed that BRE-AS1 physically binds STAT3, reduces the binding of STAT3 to the promoter of NR4A3, relieves the repression of NR4A3 caused by STAT3, and up-regulates NR4A3 expression. Consistently, NR4A3 is significantly down-regulated in NSCLC tissues and the expression of NR4A3 is positively correlated with the expression of BRE-AS1 in NSCLC tissues. In addition, depletion of NR4A3 attenuates the tumor suppressive roles of BRE-AS1 in NSCLC. |
| Pubmed ID | 30227111 |
| Year | 2018 |
| Title | Long Non-Coding RNA BRE-AS1 Represses Non-Small Cell Lung Cancer Cell Growth and Survival via Up-Regulating NR4A3 |
External Links
| Links for BRE-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |