Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot analysis, Luciferase Reporter Assay, RIP |
| Sample | neuroblastoma tissues,neuroblastoma cell lines (SK-NSH, SK-N-AS) and human umbilical vein endothelial cells (HUVEC) |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of SNHG1 and PLK4 were increased in NB tissues and cells, and miR-338-3p expression was on the contrary.SNHG1 knockdown weakened the volume and weight of tumor in vivo.SNHG1 conduced to tumorigenesis and mechanism by upregulating PLK4 and by acting as miR-338-3p sponge in neuroblastoma. |
| Pubmed ID | 31696485 |
| Year | 2019 |
| Title | LncRNA SNHG1 Contributes to Tumorigenesis and Mechanism by Targeting miR-338-3p to Regulate PLK4 in Human Neuroblastoma |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |