Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | human PC cell lines AsPC-1, PANC1, BxPC-3, SW1990, and human normal cell HPDE6 |
| Expression Pattern | up-regulated |
| Function Description | SNHG1 was significantly upregulated in PC cells. Knockdown of SNHG1 could obviously suppress cell proliferation, invasion, and migration. Furthermore, SNHG1 knockdown inhibited the activation of the Notch 1 signaling pathway and inhibited the expression of N cadherin, Hes1, Vimentin, Notch 1. The inhabitation was reversed when Notch 1 was overexpressed in si SNHG1 cells. |
| Pubmed ID | 30520072 |
| Year | 2018 |
| Title | Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch 1 signaling pathway in pancreatic cancer |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |