Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin (DDP) | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | Human bronchial epithelial cell line (16HBE) and NSCLC cell lines (A549 and H1299), DDP-sensitive NSCLC tissues and DDP-resistant NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | SNHG1 was upregulated in DDP-resistant NSCLC tissues and cell lines. SNHG1 knockdown suppressed the proliferation, migration, invasion and DDP-resistance in DDP-resistance NSCLC cell lines in vitro and inhibited tumor growth in vivo. Moreover, SNHG1 repressed miR-140-5p expression by directly binding to miR-140-5p. SNHG1-knockdown-mediated regulatory effect was antagonized by miR-140-5p. Furthermore, -catenin signaling was involved in SNHG1/miR-140-5p-mediated regulation in DDP-resistance NSCLC cell lines. |
| Pubmed ID | 31288529 |
| Year | 2019 |
| Title | Long non-coding RNA SNHG1 contributes to cisplatin resistance in non small cell lung cancer by regulating miR-140-5p/W -catenin pathway |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |